We applied a validated integrative risk-prognostication system integrative Box (iBox) as a surrogate endpoint to the TRANSFORM Study, a large randomised controlled trial, to project individual patient long-term kidney allograft survival from 1 year to 11 years after randomisation.
14 University of Paris, INSERM, PARCC, Paris Translational Research Centre for Organ Transplantation, Paris, France of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. 
14 University of Paris, INSERM, PARCC, Paris Translational Research Centre for Organ Transplantation, Paris, France 1 University of Paris, INSERM, PARCC, Paris Translational Research Centre for Organ Transplantation, Paris, France. 13 Department of Research and Development, Novartis, Basel, Switzerland. 12 Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan. 11 Division of Nephrology and Hypertension, University Hospitals of Cleveland, Cleveland, Ohio, USA. 10 Department of Surgery, Kidney Transplant Service, University of California San Francisco, San Francisco, California, USA. 9 Department of Surgery, The Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 8 Department of Renal Medicine and Transplantation, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. 7 Nephrology Division, Hospital do Rim, UNIFESP, Sao Paulo, Brazil. 6 Agostino Gemelli University Polyclinic Foundation, Catholic University of the Sacred Heart, Milan, Italy. 5 Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany. 4 Department of Nephrology and Renal Transplantation, Renal Transplant Unit, Hospital Clinic de Barcelona, Barcelona, Spain. 3 Department of Nephrology, Hospital del Mar, Barcelona, Spain. 2 Kidney Transplant Department, Necker Hospital, APHP, Paris, France. 1 University of Paris, INSERM, PARCC, Paris Translational Research Centre for Organ Transplantation, Paris, France. Ibox track and trains are all designed and manufactured by RMC at our facility in Hayden, ID. The combination of the Ibox track system and trains allow for our innovative layouts containing positive and negative g forces throughout as well as inversions. Hybrid Ibox coasters utilize RMC’s state of the art steering axle trains equipped with a class 5 restraint system. Upon completion, the new ride will be taller, faster, and more thrilling because of new elements. For existing coasters in need of a refresh, RMC offers “reprofiles.” To the extent possible, RMC will utilize existing structure and footings as the core of a new coaster. Additionally, parks with existing wooden coasters have the opportunity to modernize their rides. 
Hybrid Ibox coasters are available as custom ground up rides. that traditional wood tracks do not allow with the smooth feel of a steel coaster.
The Ibox track allows for thrilling elements such as inversions, steeper drops, high banking turns, etc. Hybrid Ibox coasters maintain the park friendly aesthetics of a “woodie,” but supercharge it with extreme elements that have never been experienced on a wooden coaster. Hybrid Ibox coasters utilize traditional wood structure in combination with steel Ibox track. Ibox track continues to be a game changer in the coaster industry. RMC pioneered the “hybrid” coaster by developing patented Ibox track.
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